 Okei. Olen näy, että paljon olet ollut suunnittaneet viimein. Joten katsotaan vähän alcoholin. Alcohol use on yksi to五 kursaaminen, matkaisu, matkaisu ja kokoa. In the United States alone alcohol use costs the society more than 250 billion dollars. On on individuallinen, Suomen kulttuurin alkuun järjestelmä on jopa yksinkertaisuksi. Nyt vielä, yksinkertaisuksi. Yksi ja 5 puolesta kulttuurin alkuun jäljelläinen jäi kulttuurin jäljelläinen. Tämä seuraavaksi on yksi kulttuurin järjestelmässä. Nyt, kulttuurin järjestelmä on erittäin hyvä, koska järjestelmä on vielä yksinkertaisuksi. Kulttuurin järjestelmä on järjestelmä, you to develop alcohol use this order later in life. However, we don't have the resources to give extensive treatment to all teenagers who drink. But we also know that not all teenagers develop alcohol related problems later in life. So what we need is a method to identify those individuals who are at highest risk. So here is my solution. Okay, maybe I need to explain a little. This is a map showing basically your health status. It has all the chemical reactions happening in every cell of your body. Now, if your map is showing only one street corner, you are measuring only one thing like cholesterol here. You are missing the big picture and are bound to get lost. Now, a method called metabolic profiling. We are able to measure most of the compounds seen in this picture. And as such, give you that overall view that we need. Now, your metabolic profile is a combination of your genetic background and the environmental influence you have experienced. And as such, it is the optimal tool for personalized preventive health care. Okay, now, so what I want to do is to develop a metabolic profiling based method that enables us to identify those young individuals who are at highest risk of developing alcohol related problems later in life. We have already started recruiting people for this study, but for the next leap forward, we need more funding. So, please help me save the brains of the future. Thank you. Thank you so much, Olli. Judges, please. Thank you. Thank you, Olli. This is a very important issue. So, actually quite the same question than for the previous one. How about this data and how about these people? How do you gather enough data or people for your study? So, we have done already a pilot study, looking at the heavy drinking in young adolescents. We are now recruiting 500 people for our next study phase. And what we need at the moment, we need two study sets, cohorts. We need one for discover phase and one for the confirmation of this. How well does our model then predict those? So, that's what we are now doing. Vince, go ahead. Sorry, I was just curious. Since you are going to be expensive to the metabolomics on all these people, but assuming that you do it, could you use the same profiling to identify also different disease predispositions so that you basically hit several with one? Yeah, what I actually see in a long run is that we would do this kind of metabolic profiling starting from childhood. Every year you would follow up people and then you are seeing that okay, this person's metabolic profile is actually shifting towards alcohol-related problems or towards type 2 diabetes or anything. So, you could then start to interview before. Just a quick question. Is it already predicted that it's just metabolic profile would be enough to determine somebody's likelihood to be alcoholic later in life? Or is that part of the study? Yeah, so we know that alcohol changes the metabolic profile. We know that some of these changes are associated with changes in the brain, function and the structure of the brain. And we know that some of the same changes actually predict how well people respond to different medications when treating alcohol use disorder. Thank you so much, judges and Olli. Yeah. Love the lizard. So you will be worn before your slash after party.