 Thank you very much. Again, I'd like to thank everybody for coming tonight and thank you to the Brain Foundations This is obviously a great opportunity and a difficult grant to get so that's really exciting So my grant is to look at exercise gene expression and Alzheimer's disease So maybe if you don't know a lot about Alzheimer's disease I'll just give you a bit of background So Alzheimer's disease is a form of dementia and it's the most common form of dementia It's caused by a build-up of proteins that lead to cell death a brain cell death Which then leads to the atrophy of the brain so they lose a lot of volume in the brain And it starts with a decline in things like memory and thinking and as the disease progresses a loss of self-care and Alzheimer's disease is a fatal condition and it does obviously end in death But to date there's no cure or treatment for Alzheimer's disease So a lot of research is starting to turn towards lifestyle measures such as physical activity as a prevention measure for Alzheimer's and Indeed, there's a lot of research showing that high levels of exercise are associated with reduced Alzheimer's disease risk, but we still don't know a lot about what's happening in that area And specifically what we want to do is get effective exercise programs So not just anything we want to be able to say this is what you need to do in terms of exercise To reduce your risk of Alzheimer's disease So my research this particular grant that I've received is building on a fellowship that I received from the NHMRC Institute of Dementia where I'm looking at six months of high intensity and low intensity exercise On measures in the brain from MRI as well as a lot of cognitive assessments looking at memory and thinking And this particular grant will fund an extension to that project where I'll be looking at gene expression And in particular looking at genes that we know were associated with Alzheimer's disease And I'll be looking at that gene expression following that exercise intervention So ultimately what we want to be able to do is say that For this particular person, this is the exercise you should be doing to reduce your risk for Alzheimer's disease And for this particular person, this is what you should be doing. So that's our aim of our research. Thank you