 The results of this study suggest that there is a lack of knowledge among community pharmacists in Jeddah, Saudi Arabia, regarding drug-drug interactions, DDIs. Only 6 out of 28 drug pairs were determined correctly by most participants. Furthermore, the overall mean score of 35.71 indicates that the majority of the studied community pharmacists did not demonstrate adequate knowledge of DDIs. These findings emphasize the importance of providing ongoing training and education programs for community pharmacists in Saudi Arabia to enhance their knowledge and understanding of DDIs, ultimately leading to improved patient care and safety. This article was authored by Nasser Emilorfi, Roiah S. Al-Kurashi, and Alan S. Al-Gharni.