 In this paper, the authors use hydrogen deuterium exchange mass spectrometry to describe how the SARS-CoV-2 spike glycoprotein has evolved its structural dynamics features and receptor binding capability from the emergence of the original Wuhan isolate to the recent Armacran variant. The findings reported shed light on the evolution of SARS-CoV-2 in the human population and the mechanisms of emergence of new variants. This article was authored by Valeria Calvarese, Antoni G. Vrobel, Joanna Toporowska, and others.