 This study investigated the association of certain risk factors with the grade of bladder cancer. It was found that opium use was strongly linked to high-grade bladder cancer, while cigarette smoking was only weekly associated with the same outcome. Additionally, older age was also found to be a significant factor for high-grade bladder cancer. This article was authored by Sharyar Zayami, Entegam Azizata, Hamid Reza Tabatibi, and others.