 Longchain acyl-CoA synthase 4, ACSL4, is an enzyme that catalyzes the biosynthesis of arachidonal CoA, which contributes to ferreptosis by triggering phospholipid peroxidation. ACSL4 also regulates fatty acid metabolism and icosanoid biosynthesis, and is a potential therapeutic target for various human diseases. This article was authored by Kai Yu Ding, Chong Bin Liu, Li Li, and others.