 A new hybrid temperature-responsive system consisting of polypyral, PP, layer, misoperous titanium surface, TMS, and bone morphogenetic protein, BMP2, is proposed for targeted delivery and release of biomolecules in tissue engineering, diagnostics, surface-enhanced therapy, and lab-onachip applications. The PP layer has a light-to-heat photothermal property that can regulate the release of BMP2. The PPY-based coatings on TMS are efficient for storage of BMP2 and can be tuned to release it under irradiation. The fabricated surfaces possess excellent biocompatibility and low cytotoxicity for MC3T3E1 cells. The released BMP2 can effectively promote osteogenic differentiation of MC3T3E1 cells, and the TMS-PPE-BMP2 system is suggested to prolong targeted release of the BMP2 for more than 25 days, which stimulates osteoblasts proliferation. The new stimuli-responsive hybrid system is promising for targeted, localized, sustained drug release and application in bone tissue engineering. This article was authored by Svetlana Ulesovic, Nikolay V. Ryskov, Daria V. Andrejiva and others. We are article.tv, links in the description below.