 This study aimed to explore and evaluate the characteristics of candidate factors associated with the metastasis and progression of high-grade serous ovarian cancer, HGSOC, using transcriptomic data, TCGA database, and immunohistochemistry. The results identified six hub genes that were correlated with the progression of HGSOC, particularly FAP and SFRP2, which might provide effective targets to predict prognosis and provide novel insights into individual therapeutic strategies for HGSOC. This article was authored by Huiping Liu, Lingju, Hongyang Cheng, and others.