 This study investigated the protective effects of Simvastatin, SAMV, on hexavalent chromium, CR-6, induced nephrotoxicity in rats. Rats were divided into four groups, control group, CR-6-U group, SAMV pretreatment group, and CR-6, plus the SAMV co-treatment group. The results showed that CR-6 caused significant increases in malondialdehyde, MDA, and decreases in glutathione, GSH, levels in the kidneys. Additionally, histopathology revealed severe renal damage in the CR-6 group. However, SAMV pretreatment significantly reduced MDA levels and improved GSH levels in the kidneys. Furthermore, SAMV also reversed the microscopic damage caused by CR-6 exposure, indicating that it has protective effects against CR-6, induced oxidative stress in the kidneys. This article was authored by Zara Gadarzi, Esmail Karami, and Massam Amadizida. We are article.tv, links in the description below.