 NRF2 is a transcription factor involved in the regulation of oxidative stress and inflammation. It is also known to be a key player in the maintenance of the redox system, which is disrupted in many non-communicable diseases such as inflammatory bowel disease, IBD. Activating NRF2 can help reduce oxidative stress and inflammation, making it a promising therapeutic target for treating and preventing these diseases. Natural kumarins derived from plants and fermented foods can activate NRF2 and thus reduce inflammation in the gut. These compounds can be used as lead compounds for the development of new drugs that could potentially treat IBD. Further research is needed to fully understand how these compounds work and how they can be used to treat IBD. This article was authored by Louise C. D. Stossi.