 niacems are lipid-based carriers used to deliver drugs in a controlled manner. This study examined the effects of various co-surfactants and drug-loading methods on the physical properties of niacems, such as particle size, polydispersity index, PDI, and encapsulation efficiency. Additionally, the morphology of the niacems was characterized using optical light microscopy. This article was authored by Amal Ali Elcordi, Cheng Xiuqiao, and Li Qiyou.