 The study reveals that Circular Ionae, Circa Ionae, Circular Syntaxon 6, Circus Tx6, strives malignancy in hepatocellular carcinoma, HCC, through the heterogeneous nuclear ribonucleoprotein D, H9PD, it's activating transcription factor 3, ATF3, its axis, while its encoded protein promotes HCC progression independent of Circus Tx6. This article was authored by Jehualu, Jongnan RU, Yunhao Chen, and others.