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Published on Oct 29, 2013
This is an interview with Lisa Schnell the winner of the EJN Best Publication Award 2013. For much of human history, one of the prevailing dogmas of medicine was that the spinal cord cannot regenerate. The discovery of the growth-inhibitory myelin component Nogo-A in the laboratory of Dr. Martin E. Schwab, and its subsequent neutralization with an antibody in vivo, has been a major turning point in the field of spinal cord injury. In the EJN research report that was selected as the winner of the Best Publication Award, the authors have conducted anatomical tracing, electrophysiology and behavioral experiments and found that, in adult rats, the combined treatment of anti-Nogo-A antibody, neurotrophin NT-3 and NR2d subunits of NMDA receptors induced the appearance of a functional "detour" around the lesion and improved recovery of function after spinal cord injury in adult rats. This novel combination treatment holds great promise to help improve the function of the damaged spinal cord. Watch this interview with Lisa Schnell, the first author and winner of the award to find out how this fantastic study came together. Read the EJN Best Publication here: http://onlinelibrary.wiley.com/doi/10...