 Silver nanoparticles, AGNPs, are an effective alternative to traditional root canal disinfectants. They have a broad spectrum of antimicrobial activity, are less toxic than other nanoparticle antibacterials, and can be used with existing endodontic materials to enhance their antibacterial properties. Additionally, AGNPs can help improve the hardness of the dentine and provide antibacterial properties when used as carriers for intra-canal medications. Despite these advantages, there are some potential drawbacks associated with using AGNPs, including cytotoxicity and tooth discoloration. Further research is needed to determine the safety and efficacy of AGNPs in endodontics. This article was authored by Farzana Afkami, Parisa Forgan, James L. Gutman, and others.