 Surgical research has made great strides in the past century, but its application in lower and middle-income countries is limited due to various barriers. These include social and cultural factors, lack of infrastructure, financial constraints, ethical considerations, and personal limitations. However, these obstacles can be overcome through concerted efforts to ensure that all people have access to the same level of medical care as those in developed nations. This article was authored by Nadim Ahmed Siddiqui, Muhammad Anish Reyes, Rehan Nasir Khan, and others.