 The study found that a mutation in the Ori1 gene caused tubular aggregate myopathy, a rare genetic disorder characterized by muscle weakness and fatigue. The mutation caused the Ori1 protein to form aggregates, leading to increased calcium influx into the cell without the presence of the STIM1 protein. This led to the development of a disease phenotype with broad implications for activation and inactivation of Ori1 channels. This article was authored by Priscilla SW Young, Megumi Yamashita, and Maroli Procria.