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Published on Dec 13, 2018
This is an audio version of the Wikipedia Article: HU-239
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"The only true wisdom is in knowing you know nothing." - Socrates
SUMMARY ======= Ajulemic acid (AB-III-56, HU-239, IP-751, CPL 7075, CT-3, Anabasum) is a synthetic cannabinoid derivative of the THC metabolite 11-nor-9-carboxy-THC that shows analgesic and anti-inflammatory effects in pre-clinical studies without causing a subjective "high". It is being developed for the treatment of neuropathic pain and inflammatory conditions such as arthritis. It does not share the anti-emetic effects of some other cannabinoids, but may be useful for treating pain and chronic inflammatory conditions where nausea is not present. Side effects include dry mouth, tiredness, and dizziness. The mechanism of action has not yet been fully established, but ajulemic acid may activate the CB2 receptor in the periphery leading to production of resolving eicosanoids. Studies in animals at doses up to 40 mg/kg show minimal psychoactivity of ajulemic acid, comparable to that produced by tetrahydrocannabinol. A composition of ajulemic acid named Anabasum (formerly Resunab) is being developed by Corbus Pharmaceuticals (formerly JB Therapeutics) for the treatment of orphan life-threatening inflammatory diseases.