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Antihistamines | Histamine receptor agonist and antagonist | Medi tutorials

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Published on Apr 14, 2018

Antihistamines | Histamine receptor agonist and antagonist | Medi tutorials

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description:
Antihistamines:

Histamines is a mediator of inflammation and stimulant of gastric acid secretion.Antihistamines are those drugs which block the histamin receptor and gives antihistaminergic effect....

H1 receptor agonist: 2-methyl histamin 2-pyridyl ethyl amine
H2 receptor agonist: 4,5 methyl histamine impromide
H3 receptor agonist: alpha-methyl histamine


Now, H1 receptor antagonist:
1st generation----
* Potent and powerful sedative: Diphenhydramine Dimenhydrinate Promethazine Hydroxyzine Doxylamine
* Potent but less sedative: Chlorpheniramine Chlorcyclizine
* Potent but less sedative: pheniramine phenindamine 2nd generation---- acrivastine cetrizine, levocetrizine loratadine, desloratadine fexofenadine

H2 receptor antagonist: Renitidine Femotidine Nizatidine Zolentidine


what are the difference between 1st generation and 2nd generation antihistamine?

1st generation antihistamine are more sedative, more lipid soluable, short duration of action and should not given student, driver, working person...

But 2nd generation antihistamine are less sedative, less lipid soluable,long duration of action and should given student, driver, working person...

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