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The growth of Clostridioides difficile ー C.ディフィシルの増殖 ー

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Published on Mar 28, 2019

Clostridioides difficile is a motile bacterium with flagella. It is a large bacillus ranging in size from 5 to 10μm and this bacteria inhabits naturally in the intestine of humans and animals. As the same as other enteric bacteria, it was required to photograph this bacteria in anaerobic environment since it cannot survive under the presence of oxygen. This bacteria divide once every 3 seconds in this video (every 45 min in real-time). In recent years, it has come to draw attention as a pathogen that spreads in hospital and causes C. difficile associated diarrhea (CDAD).

C. difficile is further an anaerobic bacterium and its species name “difficile” comes from its difficulty to isolate and cultivate. In 2016, this anaerobic bacterium has been reclassified and officially renamed from Clostridium difficile to Clostridioides difficile.

C.ディフィシルは、活発に泳ぎ回る細菌です。大きさは5~10µmほどある大型の桿菌で、人や動物の腸内に常在しています。他の多くの腸内細菌と同じように酸素があると生存できないため、酸素のない環境をつくって撮影しました。映像では約3秒に1回分裂しています(これは実際の45分間に相当します)。近年、異常増殖によりディフィシル関連下痢症(CDAD)を引き起こすことのある病原菌として注目されています。
C.ディフィシルの学名は培養が難しい(difficult)ことに由来するそうです。2016年、学名がクロストリジウム・ディフィシル(Clostridium difficile)から、クロストリディオイデス・ディフィシル(Clostridioides difficile)へと変更されました。

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