When Janey is hesitant to leave home and pursue her dream of acting in Hollywood, Grandma convinces her to go by offering to come along for moral support. Once in their shoddy apartment in tinsel town, friction grows between the women but it’s not just roommate issues: Grandma scores a role in a commercial over Janey. Fortunately, Janey finds a silver lining when she meets the dreamy Oliver, a fellow Michigander and aspiring director. Her hopes are quickly dashed when an embarrassing accident on the set goes viral and Janey becomes the “Grandma, No!” girl.
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Janey and Grandma escape their frigid Michigan hometown for the palm tree lined streets of sunny Los Angeles. Bright-eyed early-twenty-something Janey has always dreamed of becoming an actress so she and her Grandma, a quirky sixty-something with a young heart, pack up and head west where Grandma realizes she too aspires to be famous. Me and My Grandma follows the misadventures of the two best friends as they take on career, hookups, and life in Hollywood - all while saving up for a second air mattress.