"The Trouble with Fructose: a Darwinian Perspective" by Robert Lustig, MD

SLIDES: slideshare.net/​ancestralhealth/​ahs-slidesrobert-lustig

ABSTRACT: Rates of fructose consumption continue to rise worldwide, and have been linked to rising rates of obesity, type-2 diabetes mellitus, and metabolic syndrome. Elucidation of fructose metabolism in liver and fructose action in brain demonstrate three parallelisms with ethanol. First, hepatic fructose metabolism is similar to ethanol in that by accelerating the process of de novo lipogenesis, both promote hepatic insulin resistance, dyslipidemia, and hepatic steatosis. Second, fructosylation of proteins with resultant superoxide formation can result in inflammation similar to acetaldehyde, an intermediary metabolite of ethanol. Lastly, by stimulating the "hedonic pathway" of the brain both directly and indirectly, fructose creates habituation, and possibly dependence; also paralleling ethanol. On a societal level, the treatment of fructose as a commodity on the open market exhibits similarities to ethanol. Fructose induces alterations in both hepatic metabolism and central nervous system energy signaling, leading to a "vicious cycle" of excessive consumption and disease consistent with metabolic syndrome. These dose-dependent actions of fructose on the liver and on the hedonic pathway of the brain recapitulate the effects of ethanol.

Released by The Ancestral Health Symposium http://ancestryfoundation.org/ under the Creative Commons license http://creativecommons.org/licenses/by-nc-nd/3.0/

Category:

Science & Technology

Tags:

• ancestral
• health
• symposium
• primal
• paleo
• diet
• fructose

[morman29]

why is he so chubby faced if he says fructose is so bad?

[wormmy1]

@morman29 Why is Durianrider so emaciated and David Wolfe so soft and fat? :P

[bobluhrs]

speaker was not told to repeat the questions so we can hear them. great doctor and factual speech. technical part and direction below amateur.

[bobluhrs]

harder to follow since the camera stays on the doctor, and does not hit the demo.

[Esoparagon]

@antioxidants87 I think you're confused. Sucrose is indeed the sugar in fruit. It is 'sugar'. Sucrose is half fructose and half glucose. The fructose in fruit is in the form of sucrose. Refined sugar is just pure sucrose.

[mswrayn]

@antioxidants87 "Fructose stimulates previtamin D production" ... so does dietary cholesterol. "A sugar high is caused by sucrose(refined sugar), not fructose" ... sucrose IS fructose, by about half. "Give a kid a banana, the same thing happen?" ...obviously not. Of course Dr. Lustig recommends that we eat fruits, because the fructose in fruits is a) minuscule compared the content in processed foods and beverages, and b) contained in a matrix of fiber that results in a time-released digestion.

[giddeygirl]

slides are provided, see note under Like Add to Share buttons.

[giddeygirl]

what, he should look skeletal?

[ApollosPlace]

Big drag the slides are not there :(