MHC Class 1

"Class I major histocompatibility complex proteins display short peptides, or antigens, derived from normal cell proteins. Peptide-loaded MHC proteins are located on the cell surface where they can be examined by passing T cells of the immune system. The MHC complex has two subunits. The smaller subunit, b2 microglobulin, resembles an immunoglobulin domain. The larger a subunit also has an immunoglobulin-like domain which is linked to a head domain containing the antigen-binding groove. The antigen-binding groove in the MHC head domain is built from two walls composed of long alpha helices that rest on a floor composed of an eight stranded beta sheet. The peptide on display fits snugly between the helices in the groove.The peptide backbone is bound at both ends by highly conserved regions of the MHC protein. Some peptide side chains extend downwards into specific binding pockets in the groove, while other peptide side chains project upwards where they can be recognized by T cells. MHC class I proteins display their bound peptides on the cell surface for immune surveillance. Immune cells, called cytotoxic or killer T cells, for example, express T-cell receptors that bind to the MHC head domain and the bound peptide. If the cell expressing the MHC protein displays a peptide foreign to the immune system, the T cell is activated by this receptor-MHC interaction. The activated T cell then proceeds to destroy the abnormal cell. Cut-away views of this peptide-bound MHC protein complexed with a T-cell receptor reveal the exquisite precision with which the interacting surfaces fit together."

Essential Cell Biology, Second Edition
by Alberts, Bray, Hopkin, Johnson, Lewis, Raff, Roberts, Walter
copyright 2004 by Garland Science Publishing

Category:

Science & Technology

Tags:

• MHC
• class
• major
• histocompatibility
• complex
• protein
• antigen
• T-cell
• immune
• system
• globulin
• microbiology
• immunology
• cell
• biology
• biochemistry
• science

[leaffan27]

Actually, it's from an interactive CD I purchased along with one of my biochemistry textbooks

[MAlam21689]

@Celltypewhatkind APC = b cell , macrophage, dendritic cell... now all of these distribute to exogenous which means it can not bind to virus... viruses are all endogenous therefore mhc class 1 represented on all nucleated cells except for rbcs because rbcs are not nucleated only in one conditions rbc get nucleated and thats postsplenoectomy .... are the ones that mostly fight off the virus via CTL if u have a MHC class 1 deficiency ur NKCs take over [natural killer cells] goodluck!!!

[ThePesma]

They forgot to mention that the alfa3 domen is a constant part of this molecule and is responsible for recognition by cd8+ T.

[Ripside2]

@jorisvdv1989 all NUCLEATED cells...

[strek0655]

Not from coopers "The cell" but rather from essential cell biology from garland sciences. I have both.

[hasabunso]

The APC could also be from an obligate intracellular bacterial infection, as both types are processed intracellularly.

[spontaneousbaba]

hey thankyou for the upload

[vanapril428]

This person's voice is distracting, she sounds so pretentious

[jorisvdv1989]

yeah MHC class 1 is recognized by CD8+, and the APC needs to be a virus, that's why all cells have a MHC class 1 because they can all be infected by a virus..

[Celltypewhatkind]

hi

does antigen present has to be virus

[c4gray]

It's probably from the same company. I recognize the woman's voice, and the video/cartoon's layout.