DNA Damage and Protection

The genetic material DNA is under constant attack from the environment. There are two parts in this animation. The first half of the animation illustrates how DNA is damaged by reactive free radical and is protected by SOD/CAT. The second half shows methylation by the endogeneous cofactor S-adenosyl methionine (SAM). The methylation damage is reversed by action of by alkytransferase such as AGT. All the enzymes involved are represented by cute mice.

Created by:

Keith Mathieu
Class of 2007
Pharmacy




Dr. Bongsup Cho - URI Pharmacy ProfessorDr. Bongsup Cho
Professor of Biomedical and Pharmaceutical Sciences
College of Pharmacy

Category:

Film & Animation

Tags:

• DNA
• Damage
• Protection
• Antioxidant
• Radical
• methylation
• adenosyl
• methionine
• SAM
• URI
• animation

[faqirsilki]

Wal Mart sells those mice

[hgfjyrdetryu]

lol the mouse is called cat XD

[khenzeer]

the only thing i need is freaking rats in my DNA.

thanks anyway.

[mehrshadpiano]

just add a narration , it would be awesome .thanks .

[leniocouto]

Congratulations... :D

[leniocouto]

Concratulations!

[khan0047]

voice????

[anything4you05]

I always knew i had superoxide dismutase mice helping my methylation process....but nobody believed me.

[equnlimited]

Very cool video, thanks for making it!

[ironchopsticks]

wow this was boring.