science animation - histone deacetylation

quick video explains the function of a histone, and the process of deacetylation. It goes on to explain the value of anti-HDAC drugs to prevent excessive deacetylation.

Category:

Film & Animation

Tags:

• science
• animation
• uri
• pharmacy
• histone
• deacetylation
• dna
• drug
• zolinza

[seunghwane]

wow. I can't believe histone modification videos are on youtube.

[b3u3g3g3y]

It's a pretty good video. But contrary to what was presented, there's actually not a lot of evidence that HDAC overexpression contributes to the tumor phenotype. HDAC inhibitors do work, but probably not because HDACs are themselves overexpressed in tumors.

[jimsac2000]

great video, but the sound ruins the voice!

[javacodex]

The sound is over the voice! and makes it hard to understand

[thingsdemystified]

Watch it with the CC turned on. It's hilarious!

[ivanriches]

I like the music - who made it?

[RiccieBurr]

Very clever! Both on the part of the "Nature" (with the "accidental gene silencing method") and equally so in the Anti-HDAC response to attempt to correct the issue. Still, the primary question is: Why is there over-expression of HDAC in the first place? Is that known?

[analpummel]

I think a more fitting choice of audio would be DMX's "Where Da Hood At".

[generic joke about HATs]

and, like a good telomere-a-thon, I've run out of transcriptional material.

inb4slashdot.

[FatherChrismas]

The audio needs to be fixed.

[LeeDiddy990]

This is really interesting information Im going to look into more research on how cancer and how environmental agents influence gene expression in eukaryotes.

[MountainDeW06]

I just read an article about epigenetics and the effects these processes have on mental illness, drug addiction and other behaviors. The concept that outside forces shape the expression of our genes is fascinating and it is great to see the processes responsible for such modification in a well produced video. I want to learn more about this, especially about how various drugs, pollutants, bacteria, viruses and cancer modifies gene expression.