SBI4U DNA Nucleotide Excision Repair

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Uploaded by on Jan 28, 2008

SBI4U Molecular Genetics

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Education

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Standard YouTube License

  • likes, 3 dislikes

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Uploader Comments (JoseSantana123123)

  • There are several mistakes in this video, so I wouldn't recommend it for any studying. The main mistake being that the DNA repair pathway described is called nucleotide excision repair and does not recognise mispaired bases but bulky nucleotide damage as for example caused by UV light or chemicals in cigarette smoke. Mismatched bases are repaired by DNA mismatch repair which is an entirely different pathway and works completely differently.

  • Thank you for your feedback judihoffman. The video itself does in fact present the process of nucleotide excision repair which you have referred to, and not mismatch repair which corrects errors of DNA replication. I use this video as a resource for teaching my high school biology students about mutagens. The video accurately aids students in visualizing the mechanisms by which the cell can prevent potentially harmful mutations which result from mutagens such as UV light or various chemicals.

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  • DNA damage by COSMIC rays is RANDOM. Most cells die. Body cells don't count. In order to pass a "TRANSMISSIBLE GENETIC ERROR" to progeny, the cell must be a SEX CELL. DNA has places where it "prefers" to be "damaged" (maybe by design?). This reduces the randomness. The long-term result is GENETIC EVOLUTION. It may indeed be possible for a non-lethal level of increase in cosmic "background" radiation (see CME) to accelerate our evolution. But, change will take GENERATIONS. Hive mind is next.

  • nice work. Have source for the action script?

  • yay

  • it repairs potential mutations! if this isn't repaired it will become a mutation that might or might not affect the phenotype, depending where (in the dna sequence) it is located.

    I'm sorry for my bad english!

  • thanks this help me a lot!

  • THANKS

  • Does this process repair mutations? Why or why not?

  • this is not only a good picture but solve my problem.

    thanks tube team

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