Nucleotide excision repair (NER) of carcinogen adducts

This cartoon animation shows how DNA damage is fixed by a process called "nucleotide excision repair" (NER). The target is the DNA adducted by the human bladder carcinogen 4-aminobihpheny. The NER machinery represented by cartoon mice takes the problematic portion of the DNA and trash it. The missing strand is replaced by a new DNA strand.
Prepared by Josh Vallee (pharmacy student, 2007)
Bongsup Cho (professor)

Category:

Film & Animation

Tags:

• Nucleotide
• Carcinogen
• Adduct
• Repair
• Pharmacy
• URI
• Animation

[illdecidek]

ah yes, the rat enzyme, essential to the proliferation of the human species.

[mazack00]

There's no need to present the molecular biology like this, just explain how it works.

1 star. Humans aren't stupid. Dumbing things down is not needed and downright insulting.

[roodeehuh]

man, this is funny. i like the rat

[quanhuang]

Leuk bedacht :p Dit is niet onze niveau....

[Kdcloop]

JAJAJAJAJAJAJA



[onlydreaming]

RATase, cool, got it

[partylik3arckstr]

So the RAT exinuclease cleave via the SAW domains... got it!

[niceoboe]

Thank you, this was extremely informative, and very accurate. I wonder, in rats, are there tiny rats that remove damaged DNA, or do they have something else? Tiny elephants with chainsaws?

[Soldier957]

I liked this. Funny if you already know what is going on.

[MidgarHeretic]

Was that a chainsaw?

[abhijit00004]

stupid video.. really "non sense"