Embryonic Stem Cells and Disease Part 5 of 6

Brought to you by the Howard Hughes Medical Institute, this lecture by Dr. Douglas A. Melton is part of a series of lectures devoted to a discussion about the nature of embryonic stem cells and their potential use in the treatment of human disease. Understanding the mechanisms by which particular cell types are generated are of primary concern to be able to fully harness the medicinal potential of embryonic stem cells.

HHMI description:
There are two main approaches to using stem cells to fight human diseases: develop stem cells to produce therapeutic replacement cells and study stem cells as a model for understanding the biology of a disease. Significant progress has been made in producing stem cell lines that, for example, participate in the regeneration of damaged nervous tissue. Many human diseases, such as juvenile diabetes (type 1 diabetes), involve malfunctioning genes and environmental triggers. Usually, a specific type of cell is primarily affected by the disease, and the cellular dysfunction produces the symptoms. In juvenile diabetes, the insulin-producing islet cells of the pancreas are destroyed. Insulin is critical to the proper regulation of sugar by the body, and its absence causes the severe condition called diabetes. Researchers want to coax embryonic stem cells into becoming healthy insulin-producing cells. These cells might then be transplanted into people with diabetes to produce the insulin they lack. Researchers are also interested in producing stem cells that malfunction exactly like the diseased cells in order to understand fundamental aspects of the disease and also to test treatments.

Category:

Howto & Style

Tags:

• adult
• stem
• cells
• HHMI
• health
• medicine
• biology
• embryonic
• development
• regeneration
• evolution
• disease
• treatment
• parkinson's

[WayCurious]

Federal funding is available for both parthenogenesis and iPS thanks to Bush's EO 13435.

[WayCurious]

The centrosome isn't the only problem, and it would still be inefficient and put women's lives at risk. Compare to parthenogenesis - it is easily achieved w/2 eggs & avoid immune rejection or iPS which has your own DNA, safely comes from a cheek swab and has already 'cured' sickle cell in mice.

[resonancestructure]

Actually in Science, they published how one could recreate the centrosome from specific protein factor. Maybe they could inject these centrosomes into cells underoing SCNT?

[WayCurious]

Looks easy - too bad it doesn't work in primates due to imbalances between the chromosome sets, spindle pole numbers, microtubule-based molecular motors, removal of the nuclei depleting the primate oocyte of crucial proteins, and the acquired somatic cell centrosome " in part because in humans the centrosome is paternally derived. It can't be used cure diseases in humans & would just result in eggsploitation of poor women. He does a great explaning why hES would be rejected, though.