Claisen condensation. 1,3-dicarbonyls (4)

Organic chemistry: Overview of nucleophilic attacks on carboxylic acids and acid derivatives through the addition-elimination mechanism. How to make 1,3-dicarbonyls through the Claisen condensation; the Dieckmann condensation (intramolecular Claisen condensation). Reactions of 1,3-dicarbonyls—acetoacetic ester synthesis; malonic ester synthesis

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(1) Overview of nucleophilic attacks on carboxylic acids and acid derivatives through the addition-elimination mechanism
(2) Continued. Claisen condensation
(3) Continued
(4) Continued
(5) Continued
(6) Continued. Dieckmann condensation (intramolecular Claisen condensation)
(7) Continued. Claisen condensation with enolates formed from ketones
(8) Synthesis with the Claisen condensation; retrosynthesis
(9) Alkylation of 1,3-dicarbonyls. Decarboxylation
(10) Continued
(11) Continued. Acetoacetic ester synthesis
(12) Continued
(13) Malonic ester synthesis

Category:

Education

Tags:

• organic
• chemistry
• nucleophilic
• attacks
• carboxylic
• acids
• derivatives
• addition-elimination
• mechanism
• dicarbonyls
• Claisen
• condensation
• Dieckmann
• intramolecular
• reactions
• acetoacetic
• ester
• synthesis

[sa2uklost]

Thanks for your videos they've helped me a lot! I don't understand why you have made the correction to the equilibrium arrows though- this is still an equilibrium step in my opinion. The deprotonation just drives the equilibrium and therefore he reaction to completion where you can add an aqueous acid to 're-protonate' to for a beta keto product. So really the deprotonation accounts for the high yields obtained from Claisen condensation. Please correct me if I'm wrong I'm only an undergrad ty

[Sameer3292]

Thank you sir !!!!

[blatte2008]

thank you for this help, its helped me to much..

But in 10:00 i think you should write a plus instead for equilibrium.

again thank u