Upload

Loading icon Loading...

This video is unavailable.

Simulating Patient-specific Nanoparticulate Drug Delivery for the Treatment of Vulnerable Plaques

Sign in to YouTube

Sign in with your Google Account (YouTube, Google+, Gmail, Orkut, Picasa, or Chrome) to like TACCutexas's video.

Sign in to YouTube

Sign in with your Google Account (YouTube, Google+, Gmail, Orkut, Picasa, or Chrome) to dislike TACCutexas's video.

Sign in to YouTube

Sign in with your Google Account (YouTube, Google+, Gmail, Orkut, Picasa, or Chrome) to add TACCutexas's video to your playlist.

Published on Oct 1, 2012

The vast majority of heart attacks occur when there is a sudden rupture of plaques, so-called vulnerable plaques, forming clots that can cause blockages in coronary arteries. The objective of the researchers' work was to develop a computational tool-set to support the design and analysis of a catheter-based local nanoparticulate drug delivery system to treat vulnerable plaques and diffuse atherosclerosis. The goal is to rationally design drug-encapsulated nanoparticles in conjunction with patient-specific attributes and deliver drug locally to the diseased arteries, thereby personalizing and optimizing therapeutic intervention. To that end, a three-dimensional mathematical model of coupled transport of drug and drug-encapsulated nanoparticles was developed and solved numerically utilizing isogeometric finite element analysis using the Texas Advanced Computing Center's (TACC) HPC resources. The visualization component of this project, a 14 minute animation, seeks to explain the motivation of the research, the physical mechanism of the proposed solution concept, the mathematical models used, the computational methodology applied for simulation, and the scientific visualization of the results.

Researchers

Shaolie Hossain, PhD
Institute for Computational Engineering and Sciences (ICES)
The University of Texas at Austin

Thomas J. R. Hughes, PhD
Institute for Computational Engineering and Sciences (ICES)
The University of Texas at Austin

Visualization and video production

Ben Urick
Texas Advanced Computing Center (TACC)
The University of Texas at Austin

Jo Wozniak
Texas Advanced Computing Center (TACC)
The University of Texas at Austin

Erik Zumalt
Faculty Innovation Center (FIC)
The University of Texas at Austin

Audio recording and post-production

Juan Diaz
Faculty Innovation Center (FIC)
The University of Texas at Austin

Chris Nungary
Independent Audio Engineer

  • Category

  • License

    Standard YouTube License

Loading icon Loading...

Loading icon Loading...

Loading icon Loading...

The interactive transcript could not be loaded.

Loading icon Loading...

Loading icon Loading...

Ratings have been disabled for this video.
Rating is available when the video has been rented.
This feature is not available right now. Please try again later.

Loading icon Loading...

Loading...
Working...
to add this to Watch Later

Add to