How Keppra XR® (levetiracetam) Works

During a seizure, electrical signals in the brain cause the release of chemicals called neurotransmitters. These neurotransmitters help send messages between nerve cells (known as neurons). If the release of neurotransmitters happens too often or goes on for too long, there may be an overload in these electrical signals. This overload can result in a seizure.

Within the neurons, Keppra XR™ extended-release tablets attaches to specific molecules (called SV2A). These molecules are found on the surfaces of tiny structures in the neurons called vesicles. The attachment of Keppra XR™ to the SV2A molecules may help reduce the abnormal spread of signals that can lead to a seizure.

* This depiction is a hypothetical representation of the mechanism of action of Keppra XR™ based on available data; many aspects of the neurotransmission process and precisely how Keppra XR™ works to control seizures remain unknown.

Keppra XR is a prescription medicine that is used with other medicines to treat partial onset seizures in people 16 years of age and older with epilepsy.

Important Safety Information

Keppra XR is generally well-tolerated, but may not be for everyone. Ask your doctor if Keppra XR is right for you.

Like other antiepileptic drugs, Keppra XR may cause suicidal thoughts or actions in a very small number of people, about 1 in 500 people taking it. Patients should call their healthcare provider right away if they have depression, mood problems, or suicidal thoughts or behavior while taking Keppra XR.

Keppra XR may cause extreme sleepiness, tiredness, and weakness, and problems with muscle coordination. Keppra XR may also cause mood and behavior changes including psychotic symptoms such as hallucinations, delusions, and unusual behavior. Call your healthcare provider right away if you have any of these symptoms.

Do not stop taking Keppra XR unless instructed by your healthcare provider. Stopping a seizure medication all at once can cause seizures that will not stop, a very serious problem.

The most common side effects seen with Keppra XR and other formulations of Keppra include sleepiness, weakness, dizziness, and infection.

Call your doctor for medical advice about side effects. You may also report side effects to FDA at 1-800-FDA-1088 or go to http://bit.ly/SafetyMedWatch or contact UCB, Inc. at 1-866-822-0068.

Please see the Keppra XR Medication Guide at the end of the Full Prescribing Information for additional important patient information: http://bit.ly/MedicationGuide_FullPrescribingInfo

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• Keppra
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• Epileptic
• Epilepsy Medication
• Epilepsy Treatment
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