Cardiac Action Potential (Cardiomyocyte AP: part 4/6)

Cardiomyocyte AP

Category:

Howto & Style

Tags:

• human
• heart
• physiology

[hyperhighs]

@sorryca What's up with your negative attitude? If you find a mistake in any of my videos, just post a correction. I can't reply to everyone, and I certainly can't redo the video. You clearly lack the manners and professionalism of a good-hearted physician, and I would encourage people like you to avoid entering the medical establishment. Thank you.

[acetone58]

@hyperhighs he was actually technically correct. All cardiac myocytes are capable of spontaneous action potentials in their own right. This is not limited to SA, AV, and Purkinje pacemaking cells. The reason why the pacemakers are necessary is that very fact actually. The reason is probably more indepth than what would be necessary for your audience but none-the-less it's true. You can easily see this in cultures and there are many diseases which are caused by it as well.

[SunxFlowerxKiss]

@hyperhighs Could you please post a copy of your notes in pdf form somewhere so we can use it to review later when we don't have the chance to see your video before an exam? PLEASE!

[acetone58]

@isaiahnbrandon I'm not sure what the aggressiveness is. I'd be slightly annoyed if I were in sorryca's shoes as well. He pointed out a valid criticism and instead of being met with a rational explanation was tossed an explanation of something he never brought up.(he was talking about cardiac myocyte automaticity not the various "pacemaker cells) Actually, I would be fascinated to know how you, polishstud, or hyperthighs can explain cultured cells beating WITHOUT generating action potentials

[isaiahnbrandon]

@sorryca ... he did reply to your comment. he said SA, AV, and purkinje fibers were the pacemaker. not contractile cells. he is right..

[PolishStud101]

@sorryca

He DID reply to what you said. You were just too stupid to understand.

Be gone loser.

[TheTackyGirl]

Awesome!! Thanks so much!



[TheDentAmy]

thank you very much, really good stuff!! but the only thing i would point out is the blurry act of the video :( :(

regardless, AMAZING (Y)

[gigantasaur]

I have also read that beta1 mediated phosphorylation sensitises the cardiac contractile proteins to Ca2+, also increasing force of contraction?

I found this confusing because apparently the opposite effect occurs in smooth muscle, protein phosphorylation reduces the affinity for Ca2+. :/

[sahlinja]

Phospholamban is a protein that normally inhibits SERCA

pumps in the SR. Phosphorylation of phospholamban removes

this inhibition causing increased SERCA activity. SERCA resides in the sarcoplasmic reticulum (SR) within muscle cells. It is a Ca2+ ATPase that transfers Ca2+ from the cytosol of the cell to the lumen of the SR at the expense of ATP hydrolysis during muscle relaxation.

[beti05]

@MrMike00722 idiot