How Fat Stem Cells May Work on Autoimmune Diseases (Rheumatoid Arthritis, Multiple Sclerosis, etc)

Description of a paper from Diane Mathis's group at Harvard confirming high content of T regulatory cells in fat. These cells may be one of the mechanisms by which "fat stem cell therapy" works. For more information see www.stemnow.com

Category:

Science & Technology

Tags:

• fat stem cells
• multiple sclerosis
• foxp3
• t regulatory
• autoimmunity
• adipose

[stemcellscientist]

saw that you did a press release on this. It is good to know that Thomas Ichim is the "man behind the videos"

Great job and keep on publishing. This is the only time I have seen a stem cell clinic that offers treatments to patients to actually be capable of publishing in the medical journals and make videos describing what exactly the treatments are so that everyone can understand.

[MrSymposier]

I think it is a very interesting video, and that this kind of researches may help developing new treatments for different kinds of diseases and Conditions, specially in autoimmune diseases. As I understood the main idea is using peoples TREG from FAT to improve their immune System. For physicians interested in other useful videos on Autoimmune Diseases and other medical Topics, visit Symposier site.

[vdardov]

this seems like a very interesting relationship between fat cells and Treg. very informative!

[EmelinaChaCha]

Thanks for the information! Sounds very intriguing. Maybe there will be another video explaining more. Obviously people like me with M.S. can't just lose weight and be healed (although that would be nicE!) Stem cells are so fascinating.

[emirapper]

weight loss has been documented to decrease inflammation...so maybe this is mediated by the Tregs being set free...the paper discussed actually has some data that wasnt on the video showing that if you kill the fat Tregs the obese mice actually get more type II diabetic, and if you give Treg then they become more insulin responsive...very very strange relationship between fat, stem cells, Teg and inflammation

[EmelinaChaCha]

So if Treg cells are stuck in the fat, does that mean by losing weight you might set them free too?

[christineball33]

you can tell he loves to talk about these things !!!

[MCAnZiO]

Very informative video and nice use of sources....easy to follow. That's really interesting that autologous fat stem cells have such a potential for regenerative medicine. Makes you think where else are possible sources.

[angelafreedman21]

Very good use of the links to provide a overall picture of the point that is being made.

So the good cells that protect from inflammation are the Tregulatory cells that are normally inhibited by the fat when they are in stuck.  Once you take them out of the inhibitory area they are then free to go and suppress other activities.

The point that they make a lot of the protein interleukin-10 . More interleukin 10 than regulatry regulatory cells is interesting