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biosights: July 14, 2009 Microtubules gain stability by losing a tyrosine

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Uploaded by on Jul 14, 2009

The C-terminus of α-tubulin was thought to lose a tyrosine residue in response to microtubule stabilization, but new research shows that the opposite is true: tyrosine removal causes microtubules to stabilize by reducing the efficiency of depolymerizing motor proteins. This biosights episode presents a paper by Peris et al. in the Journal of Cell Biology, and includes interviews with authors Leticia Peris and Annie Andrieux. Produced by Justin Paul and Ben Short.

Read the related article online at: http://jcb.rupress.org/content/185/7/1159.full

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  • What is the difference of microtubules between loosing or gaining stability?

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