Daily rhythms of life are generated by circadian clocks that operate by transcriptional and translational feedback loops. Central components of the oscillators are PERIOD proteins containing PAS domains in tandem forming various homo- and/or hetero-dimers. Although fruit fly (Drosophila) and mammals have homologous PERIOD proteins, the homodimeric interactions between them exhibit structural differences suggesting the diversification of the machinery (ref. 1wa9.pdb: Yildiz et al. MolCel v17 p69, and 3gdi.pdb: Hennig et al. PLoSB v7 i4).
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