biosights: November 28, 2011 - CKIδ Decentralizes the Centrosome

When a T cell encounters a target antigen-presenting cell, the lymphocyte's centrosome relocalizes to a specialized contact between the two cells called the immunological synapse. Zyss et al. reveal that casein kinase Iδ helps to reposition the centrosome in activated T cells, perhaps by working with the microtubule plus-end binding protein EB1 to regulate microtubule growth. This biosights episode presents the paper by Zyss et al. from the November 28, 2011, issue of The Journal of Cell Biology and includes an interview with senior author Fanni Gergely (University of Cambridge and Cancer Research UK). Produced by Caitlin Sedwick and Ben Short.

Read the full article online at: http://jcb.rupress.org/content/195/5/781.full

Category:

Science & Technology

Tags:

• JCB
• Journal of Cell Biology
• Rockefeller University Press
• biosights
• T cell Receptor (TCR)
• cell-cell junction
• centrosome
• Casein
• kinase
• immunological synapse
• IS
• EB1
• CKI
• CKIδ--EB1
• microtubule