Dysregulation of striatal plasticity contributes to the pathology of Parkinson's disease. Anatol Kreitzer and colleagues identify RGS4 as a key regulator of synaptic plasticity in striatal neurons and show that lack of RGS4 ameliorates impairments in a mouse model of Parkinson's disease.
For more information, see Lerner and Kreitzer, Neuron 73(2).
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