GABAA Receptor Subunits and Ion Channel

GABAA receptor subunits, the GABAA receptor pentamer, and a GABA binding site and ion channel in action. (Video created by Science Approach for the NeuroVisions Phase II project, 2010.)

Category:

Education

Tags:

• GABA
• GABAA receptor
• neurotransmitter
• neuroscience
• ionotropic receptor
• GABAA receptor pentamer
• subunits
• ligand-gated ion channel
• ion channel
• ion pore
• Cl¯ channel
• GABAA receptor structure
• neuroscience tutorial
• GABA binding site
• receptor structure
• neuroscience instruction
• conformational changes
• transmembrane spanning regions
• transmembrane channel
• Science Approach
• NeuroVisions

[Zhivagoan]

beautifully done!

[AlekhThapa]

@dijieg Your correct there are two binding site for GABA molecules in GABAa receptor with that subunit conformation and binding of both molecules is required for channel opening. These two sites are between the alpha and beta subunits, one binding site per junction.

[naliniim]

@dijieg - you are probably thinking of acetylcholine binding to nicotinic muscarinic receptors, which requires two acetylcholine molecules to bind.

[dijieg]

Correct me if I am wrong, I think you need two molecules of GABA to attach to the agonist sites on the receptor

[lucaturin]

nice work !!

[msk7046]

some audio would be nice!

[pharmacy51]

very good

[pharmacy51]

thanx

[himehime90]

thanks for the video