biosights: August 8, 2011 - Nuclear envelope starts with a clean sheet

At the start of mitosis, the nuclear envelope and nuclear pore complexes break down and disperse into the endoplasmic reticulum and cytoplasm. Lu et al. use rapid, 3D live cell imaging to reveal that, in contrast to previous models, the nuclear envelope reforms directly from ER cisternae after mitosis and that this happens before nuclear pore complexes start to reassemble. This biosights episode presents the paper by Lu et al. from the August 8, 2011, issue of The Journal of Cell Biology, and includes an interview with authors Lei Lu (Nanyang Technological University, Singapore) and Tomas Kirchhausen (Harvard Medical School, Boston, MA). Produced by Caitlin Sedwick and Ben Short.

Read the related article online at: http://jcb.rupress.org/content/194/3/425.full

Category:

Science & Technology

Tags:

• JCB
• Journal of Cell Biology
• RUP
• Rockefeller University Press
• mitosis
• nuclear envelope
• nuclear pore complex
• endoplasmic reticulum
• ER
• cisternae
• membrane