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Natural Cancer Cure? Tumor Inhibitor?

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Uploaded by on Apr 24, 2008

Madrid, Spain: Compounds in marijuana inhibit malignant brain tumor growth in animals, and may provide a potential therapy for human glioma patients, according to a clinical review appearing in the September issue of Neuropharmacology.

"Current therapeutic strategies for the treatment of [gliomas] are usually ineffective or just palliative," researchers from the Department of Biochemistry and Molecular Biology at Madrid's Complutense University wrote. "During the last few years, several studies have shown that cannabinoids ... slow the growth of different types of tumours, including gliomas, in laboratory animals. Cannabinoids induce apoptosis (programmed cell death) of glioma cells [in vitro.] In addition, cannabinoid treatment inhibits angiogenesis (growth) of gliomas in vivo. Remarkably, cannabinoids kill glioma cells selectively and can protect non-transformed glial cells from death. These and other findings reviewed here might set the basis for a potential use of cannabinoids in the management of gliomas."

Last year, a clinical review in the journal Nature Reviews Cancer made similar recommendations, noting that cannabinoids possess a "favorable drug safety profile" and have shown in clinical trials to inhibit various forms of cancerous tumors, including gliomas, lung carcinoma, breast cancer, skin cancer, thyroid cancer, lymphoma, and prostate cancer.

For more information, please contact Paul Armentano, NORML Senior Policy Analyst, at (202) 483-5500. Abstracts of the review are available online at:
http://else.hebis.de/cgi-bin/sciserv.pl?collection=journals&journal=00283908




The author

For patients and their physicians, let this report serve as a primer for those who are considering using or recommending medicinal cannabis. For others, let this report serve as an introduction to the broad range of emerging clinical applications for cannabis and its various compounds.

Paul Armentano
Deputy Director
NORML | NORML Foundation
Washington, DC
January 24, 2008

* The author would like to acknowledge Drs. Dale Gieringer, Gregory Carter, Steven Karch, and Mitch Earleywine, as well as NORML interns John Lucy, Christopher Rasmussen, and Rita Bowles, for providing research assistance for this report. The NORML Foundation would also like to acknowledge Dale Gieringer, Paul Kuhn, and Richard Wolfe for their financial contributions toward the publication of this report.

** Important and timely publications such as this are only made possible when concerned citizens become involved with NORML. For more information on joining NORML or making a donation, please visit: http://www.norml.org/join. Tax deductible donations in support of NORML's public education campaigns should be made payable to the NORML Foundation.

http://norml.com/index.cfm?Group_ID=7002

_______________________________________
"Prohibition...goes beyond the bounds of reason in that it attempts to control a man's appetite by legislation and makes a crime out of things that are not crimes. A prohibition law strikes a blow at the very principles upon which our government was founded." -- Abraham Lincoln December 1840
_____________________________________
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Uploader Comments (NC420Reform)

  • This video is very helpful. thanks

  • @gadionson1 You are welcome and glad if it helped at all.

Top Comments

  • According to Dr. Donald Tashkin's research on "Does Marijuana Raise Lung Cancer Risk?". There were 611 patients that had lung cancer. The cancer patients that were tobacco-only smokers had a 20-fold increase in lung cancer elevation in two weeks when they smoked. There was zero elevation even among the heaviest of marijuana-only smokers when they smoked. Dr. Tashkin is the same guy who found that pot smoke contains the same chemicals as tobacco smoke. However, he admitted THC provides protection

  • "THC induces the cancerous cells to make a fatty substance called ceramide, which prompts the cell to devour itself. THC doesn't make ceramide with healthy cells. The healthy cells don't die."-Dr. Manuel Guzman

    "THC exhibits anti-tumor effects on various cancer cell types."-Dr. Vincenzo Di Marzo

    "THC kills cancer cells-"Dr. Liu

    "We gave THC oil drops 400 times to children that had cancer between the ages of 1-13, and it eliminated vomiting & nausea 100%"

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  • @NC420Reform Type this in Google: "PMID: 21336992" You'll love it!

  • (1 of 4) "Carboxyl group (attached to THC) doesn't allow THC to fit into the Cannabinoid receptor completely, so it needs to be Decarboxylated (removed by Rick Simpson's method) then THC can slide all the way into the receptor."

    Dr. Frankel

  • (2 of 4) "THC induces the Cancerous cell to make a fatty substance called ceramide, which prompts the cell to start devouring itself, noncancerous cells don't make ceramide when they come into contact with THC. The healthy cells don't die."

    Biochemists Guillermo Velasco & Manuel Guzmán, Complutense University

  • (3 of 4) "Normal & Cancerous Immune cells contain Cannabinoid Receptors (CB2), the CB2 can act like a target. Cannabinoids once they bind with the CB2, they can tell the Cancer cell to die. Therefore can be used effectively as an Anti-Cancer agent. The Endocannabinoids that we produce are in such small quantities and rapidly degrade."

    Dr. Nagarkatti, Prof. of Immunology, University of South Carolina

  • (4 of 4) "THC is Antimitogenic or Antiproliferative (inhibits Cancer cell division), Antiangiogenic (inhibits the growth of new blood vessels in Cancers), Proapototic (encourages old cell death before mutating then leading to Cancers) & Antitumoral (counteracting or preventing the formation of malignant tumors; anticancer). Those appear to be the mechanisms that might account for these Antitumoral effects of THC."

    Dr. Donald Tashkin, UCLA

  • @dtpheif (Cont.) Also, Dr. Tashkin admitted that the THC provided a protective effect. THC exhibits anti-tumor effects on various cancer cell types. THC binds to the protein receptors on a cancerous cell's surface, and induces a fatty substance called ceramide. The cancerous cell will then undergo autophagy(programmed cell death). Normal cells have a vast kinase checkpoint system that prevents ceramide production. While cancerous cells have a damaged kinase checkpoint system that allows ceramide

  • @dtpheif Just tell them that Dr. Donald Tashkin, a federal government researcher and pulmonary specialist at the Geffen School of Medicine at the University of California at Los Angeles, found that marijuana smoke contained just as many carcinogens as tobacco smoke in the late 90's. However, in 2006, his large case-controlled study found that marijuana only smokers had zero increase of lung cancer risk. While the tobacco-only smokers had a 20 fold increase in lung cancer risk.

  • @zekdom i was able to fit all but the end. i have a lot of conservative friends on my facebook too, and i know they will see it

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