X Inactivation and Epigenetics
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Uploaded by WEHImovies on Jan 24, 2012
X inactivation is a vital process that occurs in all DNA-containing cells of the female body. It is also an important research model and tool for studying epigenetics. Epigenetics refers to processes that tell our cells how, and when, to read the DNA blueprint. The epigenetic regulation of DNA is critical in both normal development and disease.
X inactivation is a type of gene dosage compensation.
In humans, the sex chromosomes X and Y determine the sex of an individual - females have two X chromosomes (XX), males have one X and one Y chromosome (XY). All of the genes on the Y chromosome are required in male development, while the genes on the X chromosome are needed for both male and female development.
Because females receive two X chromosomes, they inherit two copies of many of the genes that are needed for normal function. Extra copies of genes or chromosomes can affect normal development. An example is Down's syndrome, which is caused by an extra copy of part or all of chromosome 21.
In female mammals, a process called X inactivation has evolved to compensate for the extra X chromosome. In X inactivation, each cell 'switches off' one of its X chromosomes, chosen at random, to ensure the correct number of genes are expressed, and to prevent abnormal development.
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This is just too fucking awesome, I think my face exploded
1 month ago in playlist Animations 16
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These animations are easily the best media productions in the history of the universe. [tear drop]
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WEHI makes the best quality animations of this type by far! Definitely some nice artistic style and with attention to detail and accuracy. I would like to know what software is used to in the whole workflow to produce these animations?
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Love the sound effects !
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Epicgenetics.
Absolutely fantastic video!
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Epicness at it's finest.
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Thanks everyone!
@mdoerkse We use Maya for animation and After Effects for compositing.
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