Cannabis Receptors

A layman's talk about how and why cannabis works

Category:

Education

Tags:

• marijuana
• health
• THC
• receptors
• medicine

[EssiacHempLaetrile]

Don't block with Mother Nature!

Drugs that Block Cannabinoid Receptors Seem Problematic

Merck announced that its drug Taranabant (CB1 blocking) had caused unacceptable side effects (anxiety & depression) in a Phase III trial with obese patients. When an FDA panel unanimously rejected Sanofi’s application for Rimonabant (CB1 blocking). It cited sharp increase rates of anxiety, depression, suicidal thoughts & mood disorders.

The DANA Foundation

[doctorbobcannabuzz]

@EssiacHempLaetrile Hu The easy way to think about a CB1 inhibitor is that it will make you less high, obviously going in the wrong direction. Anybody with a brain who knows cannabis could have predicted these results for a lot less money that the drug companies have spent to find this out.

[bon3sx]

BEST VIDEO ON YOUTUBE!!! I'm tryin to spread this to as many people as possible but most just don't care. It's ok tho little by little we'll keep up knowledge and information leads to truth and good will prevail as a result. Keep it up stay positive thank you dr. cannabuzz you are amazing GOD BLESS YOU and thanks for this information to consider for us all!!!!! :)

[doctorbobcannabuzz]

@bon3sx Thanks for your kind words The truth will win in the end.

be well,

drbob

[ducky923]

I was wondering what you thought about people, like myself, who have bad reactions to smoking cannabis. Nothing physical, but mental...ie paranoia. Is it some sort of chemical imbalance? And can it be helped? It doesn't happen everytime, like when I first started smoking it, but then it got to where I had to stop. Could you comment on this? Also I was wondering if i started taking hemp seed oil it might help the chemical imbalance in my brain and fix the problem? Just a theory?

[doctorbobcannabuzz]

Hi, I too have had, and do have, the same mental experiences that you describe. I used/use them as learning experiences to try an improve myself. There is so much shit that flows through our minds if we are open and perceptive. The key to growth is to latch on to the good ones and let them nourish you, while letting the crap just flow by. This is part of the nature of the personal work we can do to improve our lives and those of our family, friends and community.

[EssiacHempLaetrile]

@zekdom you missed my 8 month old message in my Channel Comments..

-Dr. Guzman, Spain, Tel: 34-91394-4668, "THC induces the Cancerous cell to make a fatty substance called ceramide, which prompts the cell to start devouring itself, noncancerous cells don't make ceramide when they come into contact with THC. The healthy cells don't die."

[EssiacHempLaetrile]

Cannabinoid Receptors (CB1 & CB2) are in our skin, brain, retina, pancreas, uterus, immune system, intestines, colon, liver, spleen, kidney, ribs, white blood cells, heart, central nervous system, bones & bone marrow (stem cells) etc. Without the 600+ Million year old Endocannabinoid System*, Stem Cells would act like a car without a driver.

*Dr. Guy, Executive Chairman of GW Pharmaceuticals

[smartypantzduh]

@ducky923 This may sound dumb but you got to remember that thc is a very very mild form of acid. you wont die or see crazy shit but some people cant just blaze up anywhere watch your environment and who your around make sure you have nothing pressing needing to be done soon (for stress reasons not lazy) whatever you can do to be for comfortable can and will help your case.

[zekdom]

@Westwood1816 (continued...) "...immortalized cells usually have flawed kinase checkpoint systems, which allows ceramide production" is what I meant to say in the previous post. Healthy cells usually have a vast kinase checkpoint system that have safeguards to prevent ceramide accumulation. Cancer cells also, in general, express either CB1 receptors or CB2 receptors (sometimes both). That may explain why THC has an anti-tumor effect.

[zekdom]

@Westwood1816 I've heard of the endocannabinoids. Anandamide is supposedly a(n) agonist that activates the cannabinoid receptors 100% of the time. While THC is a partial agonist, only activating these receptors 60-70% of the time. You are correct, cancer cells are immortalized cells that tend to fail the signals of autophagy. THC's role is to reinstate autophagy in immortalized cells that usually flawed kinase checkpoint systems, which allows ceramide production...(continued)

[Westwood1816]

@zekdom The answer to your question is the EC System. It's the greatest discovery of the 21st century as far as I can see. It's the densest system of cells receptors in our body and it homeostatically regulates every organ system on a sub-cellular and cellular level. To my knowledge all cancers have a common gene mutation that causes them to be immortal and therefore not in homeostasis. When their EC receptor is activated, by definition, they must die.

[zekdom]

@Westwood1816 No, I just care about the movement and am seeking to further educate myself about THC's proapoptotic effects. What are you? Just a guy that looks at a few journals/studies, and then act like it's adequate? Possibly, but we need strong advocates for this that can thoroughly explain how THC differentiates between healthy cells and cancer cells, or the anti-cannabis people will use that against us. Don't be naive, because it happened to me. It could ruin the movement (if we got far).

[Westwood1816]

@zekdom ...only in cancerous cells, not healthy cells in the middle of their life cycle. Of course plant-derived cannabinoids activate cannabinoid receptors...that's why it get's us high or stoned. As for your last question, who cares? What are you a biology professor?

[zekdom]

@doctorbobcannabuzz Salutations, I would very much appreciate it if you explained to me specifically how THC kills a cancerous cell. Yes, I am familiar with ceramide production, but why doesn't THC accumulate ceramide in healthy cells? Why just cancer cells? Does it have something to do with the kinase-checkpoint system? Does regular, plant-derived THC activate the cannabinoid receptors? How does THC arrest the cell cycle, if it does? I need answers, and it is your job to inform me of this.

[zekdom]

@EssiacHempLaetrile Well, are you now able to explain specifically how THC kills a cancerous cell, while ignoring healthy cells? Or are you just going to keep bashing people with scientific articles that can be contradicted by other studies? You need to be able to comprehend the mechanisms, and explain it. So, I'll ask one more time.

Why doesn't THC induce ceramide into healthy cells? If it does for cancer cells, then why wouldn't it for healthy cells?

[zekdom]

@Westwood1816 So, activation of cannabinoid receptors induces cell cycle arrest and autophagy? Can regular, plant-derived THC activate these receptors? Are cannabinoid receptors, by chance, protein receptors?