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Attacking Tumor Vasculature, Rate My Science

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Uploaded on Nov 4, 2008

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Angiogenesis is a fundamental step in the transition of tumors from a dormant state to a malignant state.
Therapeutic angiogenesis is the application of specific compounds which may inhibit or induce the creation of new blood vessels in the body in order to combat disease. The presence of blood vessels where there should be none may affect the mechanical properties of a tissue, increasing the likelihood of failure. The absence of blood vessels in a repairing or otherwise metabolically active tissue may retard repair or some other function. Several diseases (eg. ischemic chronic wounds) are the result of failure or insufficient blood vessel formation and may be treated by a local expansion of blood vessels, thus bringing new nutrients to the site, facilitating repair. Other diseases, such as age-related macular degeneration, may be created by a local expansion of blood vessels, interfering with normal physiological processes.
Design & production: Kosi Gramatikoff, PhD; client: Kristiina Vuori, MD PhD

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