Effects of HBOT on Cerebral Metabolism and intracranial pressure in Brain Injured Patients

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"Rockswold SB et al. Effects of hyperbaric oxygenation therapy on cerebral metabolism and intracranial pressure in severely brain injured patients. J Neurosurg 2001 Mar;94(3):403-11.
Please note that HDOT has been substituted for HBO in this summary of the summary.
A prospective randomized trial has already shown that hyperbaric oxygenation therapy (HDOT) reduces the mortality of severely brain-injured patients by 50%. In this study the effects of HDOT on cerebral blood flow (CBF), cerebral metabolism, and intracranial pressure (ICP), have been measured in an attempt to determine the optimum frequency of treatment. 100% at 1.5 atm absolute was delivered to 37 patients for 60 minutes every 24 hours (maximum of seven treatments/patient). The increased cerebral metabolic rate of oxygen (CMRO2) and decreased cerebrospinal fluid (CSF) lactate levels after treatment indicate that HDOT may improve aerobic metabolism in severely brain-injured patients. This is the first study to demonstrate a prolonged effect of HDOT treatment on CBF and cerebral metabolism. On the basis of their data the authors suggest that shorter, more frequent exposure to HDOT may be better.

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