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On a remote top-secret research facility called Aquatica, a team of scientists are searching for a cure for Alzheimer's disease. One of them, Dr. Susan McAlester (Saffron Burrows), violates the code of ethics, and genetically engineers three Mako sharks, intending to increase their brain capacity so that they can harvest the tissue as a cure for Alzheimer's. Unfortunately, the increased brain capacity also makes the sharks smarter, faster, and more dangerous. Aquatica's financial backers are skeptical and nervous about the tests, and send a corporate executive (Samuel L. Jackson) to visit the facility.
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