How Does Hyperbaric Oxygen Therapy Work? Part 2

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Hyperbaric oxygen therapy (HBO) was first proposed as a treatment for cancer and other conditions in the 1960s. At the time, research studies did not achieve any reproducible results, which engendered much skepticism among medical personnel. This skepticism even extended to HBO's use in treating clinical conditions that it had previously been shown to help. It was not until the 1970's that surgeons of the head and neck region came to recognize the value of hyperbaric oxygen in treating damage of the maxilla and mandible occurring during radiation treatments.

Research into this therapy has since shown HBO to be effective when used in addition to conventional therapies for the prevention and treatment of osteoradionecrosis. There is also evidence to suggest that HBO may be helpful as a therapy for soft tissue injury caused by radiation, as well as restoring tissues and cells damaged by chemotherapy and radiation treatments. It has been in the field of treating osteoradionecrosis that hyperbaric oxygen therapy has seen some of its most dramatic successes.

When osteoradionecrosis develops, tissue destruction devolves into breakdown of overlying tissues and symptomatic destruction of bone. During this process, the response to antibiotics can be poor. In many cases, the situation can be improved with the use of HBO therapy.

Hyperbaric oxygen has been shown to be more effective than penicillin. Patients being treated with penicillin typically show a significantly higher rate of necrosis than those being treated with hyperbaric oxygen, with only five to thirty percent of patients able to expect remission of ORN through conservative therapy. HBO therapy is especially beneficial for high-risk patients, such as irradiated patients requiring tooth extraction.

Hyperbaric treatment allows more oxygen to reach the damaged areas, and helps prevent tissues from dying from lack of blood and oxygen flow. The therapy is painless, and it is capable of producing a wide range of effects, including increased oxygen delivery to injured tissue, greater blood vessel formation, advanced wound healing, improved infection control, preservation of damaged tissue, elimination of toxic substances, and reduced effects from toxic substances.

Hyperbaric oxygen therapy appears to assist in salvaging tissue damaged by radiation therapy by stimulating angioneogenesis in tissue that is even marginally viable. In reconstructive surgery involving irradiated tissue, HBO treatment prior to surgery can help promote a well-vascularized wound, enhancing healing and the reconstructive process.

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