The movie shows a differentiated mononucleated cardiomyocyte expressing a GFP tagged H2B fusion construct. Time-lapse video microscopy shows this cardiomyocyte undergoes karyokinesis (nuclear division), followed by cytokinesis (cellular division). This mononucleated cardiomyocyte completes the cell-cycle giving rise to two daughter cardiomyocytes.
Credit: K. Bersell et al., Cell 138:257-70, July 24, 2009
If we give a drip of IL-2 and IL-4, defective cells are replaced by the heart's own stem cells. While tehy are not cleared, they are not replaced.
JonThm 2 years ago