fMRI reveals declined activation in patients with epilepsy on topiramate

Jansen JF, Aldenkamp AP, Marian Majoie HJ, Reijs RP, de Krom MC, Hofman PA, Eline Kooi M, Nicolay K, Backes WH. Epilepsy Behav. 2006 Aug;9(1):181-5. Functional magnetic resonance imaging of covert word generation was used to examine brain activation abnormalities associated with topiramate-induced cognitive language impairment in patients with epilepsy. Compared with a control epilepsy group, in the topiramate-treated group, there was significantly less activation in the language-mediating regions of the prefrontal cortex; the topiramate group also had significantly lower neuropsychological language scores. These findings suggest that topiramate has a critical effect on the cerebral neural systems that mediate expressive language. This paper was presented at ISMRM 2006 in Seattle.

Category:

Science & Technology

Tags:

• epilepsy
• topirmate
• side effects
• fmri
• ismrm