This is part 1 (of nine parts) of the Preventing and Reversing Alzheimer's Disease presentation, an earlier version of which was presented to the San Francisco bay area Smart Life Forum in January of 2009. This part covers the verbal introduction and the falling-dominoes illustration of the Alzheimer's cascade.
@swfowkes Right which is why even double blind studies are not trusted without extensive replication and elucidation of a mechanism. It is a very difficult process indeed but it is much better than just going with plausible explanations. Even those 50-90% false positive figures (frightening I agree) represent more certainty than good stories based on known facts. In fact that is the starting point of those studies that are so flawed.
michalchik 5 months ago
@swfowkes I'm not the one making a claim, you are. The burden of proof is on you.
Guitcad1 5 months ago
@Guitcad1 : Ask and ye shall receive. Or, better yet, engage your own values in finding the source material for yourself. People who find source material for themselves value it more. In this day and age, the technology abounds on so many levels. The bottleneck in progress is not references, but imagination. As long as people believe that Alzheimer's disease is a death sentence, it will be, for them. I'm speaking to early adopters. Their results will compel studies in 20 years.
swfowkes 5 months ago
@michalchik : But when you make decisions in the world, you can only make wise (as opposed to informed) decisions when you have an appreciation for the what-you-don't-know side of the pro-con equation. Knowing is not the simple thing that most believe. John Ioannidis is showing deep statistical flaws in the current gold standard for knowing (the double-blind study), in which 50% to 90% of unequivocal studies are found to be erroneous within 20 years. Ouch.
swfowkes 5 months ago
@michalchik : But when you make decisions in the world, you can only make wise (as opposed to informed) decisions when you have an appreciation for the what-you-don't-know side of the pro-con equation. Knowing is not the simple thing that most believe. John Ioannidis is showing deep statistical flaws in the current gold standard for knowing (the double-blind study), in which 50% to 90% of unequivocal studies are found to be erroneous within 20 years. Ouch.
swfowkes 5 months ago
@shodanxx : Thank you for the honorary doctorate. But my degree in organic chemistry is a Bachelors degree, and a Bachelor of Arts degree, to make it even more amusing. (Reed College does not do Bachelor of Science degrees.) And you are right about how science is done, 1) about how institutional science is done, and 2) how the art of science is done. My articles on the CERI web site expose multiple scientific frauds. Critical thinking is good, but expansive thinking is its complement.
swfowkes 5 months ago
@michalchik: Good point. But the Alzheimer's research community will take ten years to test this, if ever. So until Hell freezes over, I want the technology in the hands of the people who can use it. I learned a big lesson from the divergent outcomes from my efforts on behalf of Down's syndrome children, which were successful, and on behalf of GHB consumerism, which did a belly flop off the high dive. Change through grass-roots effort works. Change through media and government doesn't.
swfowkes 5 months ago
@michalchik: Good point. But the Alzheimer's research community will take ten years to test this, if ever. So until Hell freezes over, I want the technology in the hands of the people who can use. I learned a big lesson from the divergent outcomes from my efforts on behalf of Down's syndrome children, which were successful, and on behalf of GHB consumerism, which did a belly flop off the high dive. Change through grass-roots effort works. Change through media and government doesn't.
swfowkes 5 months ago
@jontycampbell: I also have the one-page summary graphic that keeps repeating throughout the series in high rez. Would this be useful? I am currently loading pdf and graphics files on the Project Wellbeing site under the "Steve" tab. I could put it there. Let me know. (my apologies for the site interface, I'm looking for better)
swfowkes 5 months ago
@8333P: Thetranslation of this information into the practical was originally untended to be a Reversing Alzheimer's Disease (in your spare time) supplementary video, done in a black-comedy style channeling Letterman for the top-ten therapies. But the project never reached critical mass, so I posted it to the Project Wellbeing website in script form. I am also initiating a series of posts there about the practical therapeutic issues, which could easily become dialogs. Only 6 posts so far.
swfowkes 5 months ago