Evolution of Nuclear Receptor Superfamily

Nuclear receptors (NR) are transcription factors composed of DNA-binding and ligand-binding domains (LBD) and coded by many genes in animals, and some of them seem to be orphans without ligand-binding capabilities. Recently sequenced genome of the most anciently branching metazoa, sponge Amphimedon queenslandica, contains two NR genes, with the LBD phylogenically related to HNF4 of various animals including human and are activated by the binding to fatty acids. It was postulated that the ancient NR had the ligand-binding capability and the divergence and the loss occurred many times in various lineage of this superfamily of proteins. In this video, five mammalian LBD structures (3FS1.pdb, 1YOW.pdb, 1PK5.pdb, 1YJE.pdb, 1DB1.pdb) are shown with colored alpha-helices.

Category:

Science & Technology

Tags:

• gene
• music
• video
• evolution
• nuclear
• receptor
• superfamily
• protein
• ligand-binding
• domain
• Nobuo
• Munakata
• Max/MSP/Jitter
• Absynth