Blocking Leptin Increases T Regulatory Cells (Increasing Efficacy of Stem Cell Therapy?)

see www.stemnow.com Mesenchymal stem cells increase T regulatory cells, which may be one of the reasons why responses have been seen in animal models of multiple sclerosis and rheumatoid arthritis. Here we discuss a paper (De Rosa et al. Immunity 26:241) showing that blocking leptin can increase T regulatory cells. In the future it may be able to combine blockade of leptin with stem cells for treatment of autoimmunity.

Category:

Science & Technology

Tags:

• T regulatory cell
• stem cell therapy
• multiple sclerosis
• rheumatoid arthritis
• leptin
• obesity
• adipose mesenchymal

[cellmedicine]

yes but leptin causes weight-loss, so you may not want to give it to cancer patients since it may accelerate cachexia

[MrSymposier]

I think this is a great discovery because both diseases presented (multiple sclerosis and rheumatoid arthritis) are very uncomfortable to live with, not to mention degenerative. Hopefully soon the combine of T cells and blockade of leptin will be a reality and patients can improve their health. At Symposier site there is more information for physicians interested on Rheumatoid Arthritis and other medical topics.

[lighthouseshines]

interesting angle on how the body self regulates itself...immunology is very interesting, especially how it is combined wtih stem cells in these videos

[troopermission]

another

great

scietnific discussion

[floricabatu]

excellent video Tommy

[angelafreedman21]

thats why you would use the leptin in a post surgical setting BEFORE the patient becomes cacketic

[stemcellscientist]

Interesting that hormones can produce such effects. I was unfamiliar with leptin, although now that i think about it, I think i remember the company Amylin here in town was working on using this as an anti-obesity drug. Maybe this is a brand new use for leptin ! to stop these T regulatory cells in patients who have cancer or where you actually want to stope the t regulatory cell attack